Staff Members - Benha University
Choosing Between Enoxaparin and Fondaparinux for the Prevention of Thromboembolism: A Meta-Analysis of Randomized Trials
• 2022
Publication Information
Authors
Enas W. Mahdy∗, Ahmed Mostafa Abd El-Hamid, Reham Mahmoud Shady, Basem Mofreh Aglan
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publication.type
Local
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Abstract
Background: Venous thromboembolism (VTE), are few of the most serious complications in ICU. There are Pharmacological
and mechanical prophylaxis methods are used to reduce the risk of thromboembolism and the most efficient is the pharmacological
methods which is based on a fine balance between their efficacy and the adverse effects associated with them.
Objectives: To evaluate, effectiveness, and clinical impact of VTE prophylaxis with fondaparinux and enoxaparin on patient
outcomes in different clinical practices.
Study design: Meta-analysis was used to address this concern.
Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and
MetaAnalyses) guidelines.
Methods: Online databases (PubMed/Medline, EMBASE, and Cochrane library) were used for randomized studies which
compared differences in clinical outcomes observed with the use of Fondaparinux and enoxaparin in patients who were treated for
thromboembolism.
Results: Thirteen studies were identified for inclusion in this study, involving a total of 64,350 patients. The risk of bias was low.
Meta-analysis found that Fondaparinux result in significant reduction in incidence of bleeding than Enoxaparin (R.R.=0.85 [0.81,
0.88]; 95% CI; I
2=100%; P
and mechanical prophylaxis methods are used to reduce the risk of thromboembolism and the most efficient is the pharmacological
methods which is based on a fine balance between their efficacy and the adverse effects associated with them.
Objectives: To evaluate, effectiveness, and clinical impact of VTE prophylaxis with fondaparinux and enoxaparin on patient
outcomes in different clinical practices.
Study design: Meta-analysis was used to address this concern.
Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and
MetaAnalyses) guidelines.
Methods: Online databases (PubMed/Medline, EMBASE, and Cochrane library) were used for randomized studies which
compared differences in clinical outcomes observed with the use of Fondaparinux and enoxaparin in patients who were treated for
thromboembolism.
Results: Thirteen studies were identified for inclusion in this study, involving a total of 64,350 patients. The risk of bias was low.
Meta-analysis found that Fondaparinux result in significant reduction in incidence of bleeding than Enoxaparin (R.R.=0.85 [0.81,
0.88]; 95% CI; I
2=100%; P