Staff Members - Benha University
The possible protective role of Moringa Oleifera and Vitamin E on Doxorubicin-induced cardiotoxicity in adult albino rats: Histological and Immunohistochemical study
• 2023
Publication Information
Authors
Randa Samy Metwally, Mohammed Mahmoud Yousef, Al-shimaa Ezzat Abdelfatah, Rania Ibrahim El-desoky
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Doxorubicin (DOX) is highly effective anti-neoplastic agent, but it has side effects including cardiotoxicity. Moringa oleifera and vitamin E are potent antioxidants that prevent cardiotoxicity.
Objective: evaluate the possible protective role of moringa oleifera and vitamin E on doxorubicin-induced cardiotoxicity.
Materials and Methods: Sixty-five adult male albino rats were randomly divided into five groups. Group I (control group). Group II (affected group): rats were injected intraperitoneally with a cumulative dose of 15 mg/ kg of DOX for three weeks. Group III (moringa group): given in a dose of (500 mg/ kg/ day) by gastric tube orally for four weeks. Group IV (vitamin E group): given in a dose of (100 mg/ kg/ day) by gastric tube orally for four weeks. Group V (moringa and vitamin E). Heart specimens were taken and prepared for histological, immunohistochemical and EM examination.
Results: Group II showed disorganized, widely separated muscle fibers, cytoplasmic vacuolation, pyknosis of many cardiomyocyte nuclei, the mitochondria appeared distorted, extravasation of RBCs and inflammatory infiltrations. There was significant increase (P
Objective: evaluate the possible protective role of moringa oleifera and vitamin E on doxorubicin-induced cardiotoxicity.
Materials and Methods: Sixty-five adult male albino rats were randomly divided into five groups. Group I (control group). Group II (affected group): rats were injected intraperitoneally with a cumulative dose of 15 mg/ kg of DOX for three weeks. Group III (moringa group): given in a dose of (500 mg/ kg/ day) by gastric tube orally for four weeks. Group IV (vitamin E group): given in a dose of (100 mg/ kg/ day) by gastric tube orally for four weeks. Group V (moringa and vitamin E). Heart specimens were taken and prepared for histological, immunohistochemical and EM examination.
Results: Group II showed disorganized, widely separated muscle fibers, cytoplasmic vacuolation, pyknosis of many cardiomyocyte nuclei, the mitochondria appeared distorted, extravasation of RBCs and inflammatory infiltrations. There was significant increase (P