The human papillomavirus (HPV) causes the common, transient cutaneous condition known as warts. It is infectious, disfiguring, and occasionally benignly koebnerizes. Immunotherapy, which stimulates the immune system, is the most frequent treatment for warts. Even though vitamin D impacts cell proliferation and differentiation, the vitamin D injections effect on wart therapy is unknown. Vitamin D increases the synthesis of antimicrobial peptides, including lymphopiotin and cathelecidin, by upregulating VDRs on immune cells and keratinocytes of the skin. A deficiency in vitamin D may increase the HPV infection incidence by raising the host's susceptibility to HPV penetration and decreasing its capacity to remove the virus.