Background: Bronchial asthma is one of the most common chronic
pediatric diseases. It is a heterogeneous disease with multiple
overlapping phenotypes. Biomarkers have been investigated for
better phenotype characterization and to identify the response to
targeted therapies. Purpose: The study aimed to assess serum
periostin level and mean platelet volume in children with asthma
flare-ups compared to age and sex-matched healthy controls.
Methods: This case-control study included one hundred asthmatic
children and fifty healthy children as controls. Both groups were
aged 6-12 years. Bronchial asthma was diagnosed according to the
Global Initiative for Asthma (1). Blood mean platelet volume and
serum periostin levels were assessed for both groups. Results: The
mean platelet volume was significantly lower in the patients group
(9±1 fL) than in the controls (11±1 fL) (P < 0.001). Serum periostin
was significantly higher in the patients group (78.85±26.33 ng/ml)
than in the controls (42.72±3.4 ng/ml) (P