Objective: the ability of SUPAR (soluble urokinase plasminogen activator receptor) to evaluate sepsis and predict mortality in critically ill children in pediatric intensive care unit (PICU). Methods: the study included 70 critically ill children admitted to PICU , divided into two groups group (A)(critically ill children with sepsis)& group (B) (critically ill children without sepsis(SIRS)) compared to matched age ,sex 30 healthy children as a control group. Clinical examination was performed ,including calculation of the pediatric Risk of mortality (PRISM) and (q sofa) in first 24 hr of admission. Results: suPAR level was significantly higher among the total patient study group compared to controls (p