LC is the gold standard treatment of gall stones. Ultrasonic scalpel causing three effects that act synergically: cavitation, coaptation/coagulation, and cutting. to Compare between Clipless laparoscopic cholecystectomy and conventional laparoscopic cholecystectomy as regard the post-operative complications (pain, infection, leakage, . etc ) , early post-operative recovery , hospital stay etc. This was prospective study, that was conducted in General Surgery Department of Benha University Hospital after an approval from the research ethics committee in Benha Faculty of Medicine and all patients signed informed consents that they was involved in this study.As regard our study in Group A mean Hospital stay (in days) was (2.21), while in Group B mean Hospital stay (in days) was (2.24), There’s no statically significant difference between two groups in respect of Hospital stay. In Group A: post-operative infection was in one case, while in Group B post-operative infection was in 2 cases, and there was no post-operative bile leak in both groups.The energy sealing devices provides complete hemobiliary stasis for all patients and is a safe alternative to stander clip of cystic duct and artery. It provides a shorter operative duration, , and less blood loss and less rate of conversion to open cholecystectomy.