Staff Members - Benha University
Serum suPAR and Urinary Nephrin as Novel Sensitive and Specific Markers for Diabetic Nephropathy in Patients with Type 2 DM
• 2023
Publication Information
Authors
Amr M. Elhammady1
*, Hend S. ELShafie1
, Asmaa A. El Fallah2
, Medhat A. Khali
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: The most frequent reason of end-stage kidney disease (ESKD) is diabetic nephropathy (DN),
highlighting the need of early detection, treatment, and prevention.
Objective: To assess the sensitivity and specificity of serum (soluble urokinase-type plasminogen activator receptor
(suPAR) and urinary nephrin in cases with type 2 diabetes mellitus (T2DM) with and without nephropathy.
Methods: This prospective study was conducted on 70 patients of T2DM and 15 healthy control group of age and
sex matched persons. All patients and control group were subjected to pelviabdominal U/S, laboratory investigations
(CBC, ESR, liver and kidney function test, fasting and 2 hours post prandial blood sugar, urine analysis, (urine
albumin creatinine ratio (UACR), nephrin, and serum suPAR levels). Results: ROC analysis was done for suPAR to
predict DN. It showed a significant AUC of 0.869, with a 95% CI ranging from 0.785 – 0.953 (P < 0.001). The best
cutoff was > 82.3, at which sensitivity and specificity were 97.1% and 68.6%, respectively. ROC analysis was done
for urinary nephrin to predict DN. It showed a significant AUC of 0.760, with a 95% CI ranging from 0.642 – 0.877
(P < 0.001). The best cutoff was > 10.8, at which sensitivity and specificity were 80% and 68.6%, respectively.
Conclusions: In T2DM patients, serum suPAR and urinary nephrin were more specific and sensitive markers than
microalbuminuria in early detection of DN
highlighting the need of early detection, treatment, and prevention.
Objective: To assess the sensitivity and specificity of serum (soluble urokinase-type plasminogen activator receptor
(suPAR) and urinary nephrin in cases with type 2 diabetes mellitus (T2DM) with and without nephropathy.
Methods: This prospective study was conducted on 70 patients of T2DM and 15 healthy control group of age and
sex matched persons. All patients and control group were subjected to pelviabdominal U/S, laboratory investigations
(CBC, ESR, liver and kidney function test, fasting and 2 hours post prandial blood sugar, urine analysis, (urine
albumin creatinine ratio (UACR), nephrin, and serum suPAR levels). Results: ROC analysis was done for suPAR to
predict DN. It showed a significant AUC of 0.869, with a 95% CI ranging from 0.785 – 0.953 (P < 0.001). The best
cutoff was > 82.3, at which sensitivity and specificity were 97.1% and 68.6%, respectively. ROC analysis was done
for urinary nephrin to predict DN. It showed a significant AUC of 0.760, with a 95% CI ranging from 0.642 – 0.877
(P < 0.001). The best cutoff was > 10.8, at which sensitivity and specificity were 80% and 68.6%, respectively.
Conclusions: In T2DM patients, serum suPAR and urinary nephrin were more specific and sensitive markers than
microalbuminuria in early detection of DN