Staff Members - Benha University
Active principle from Moringa oleifera Lam leaves effective against two leukemias and a hepatocarcinoma
African Journal of Biotechnology • 2010
Publication Information
Authors
Mutasim M. Khalafalla1, Eltayb Abdellatef1, Hussain Mohammed Dafalla1, Amr A. Nassrallah2,Khalid M. Aboul-Enein3, David A. Lightfoot4, Fadl E. El-Deeb5and Hany A. El-Shemy
Keywords
Moringa oleifera, anti-cancer, acute lymphoblastic leukemia, acute myeloid leukemia,
hepatocarcinoma
Journal
African Journal of Biotechnology
Publisher
Not Available
Volume
Vol. 9
Issue
49
Pages
8467-8471
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Medicinal plants are important elements of indigenous medical system that have persisted in
developing countries. Many of the pharmacological principles currently used as anticancer agents were
first isolated from plants. However, some important anticancer agents are still extracted from plants
because they cannot be synthesized chemically on a commercial scale due to their complex structures
that often contain several chiral centers. The aim of this study was to test different extracts from the
leaves of Moringa or drumstick tree (Moringa oleifera) for activity against leukemia and
hepatocarcinoma cells in vitro. The extracts could kill majority (70 - 86%) of the abnormal cells among
primary cells harvested from 10 patients with acute lymphoblastic leukemia (ALL) and 15 with acute
myeloid leukemia (AML) as well as a culture of hepatocarcinoma cells (75% death), but most
significantly by the hot water and ethanol extracts. In conclusion, M. oleifera may have potential for use
as source of natural treatment for diseases such as cancer
developing countries. Many of the pharmacological principles currently used as anticancer agents were
first isolated from plants. However, some important anticancer agents are still extracted from plants
because they cannot be synthesized chemically on a commercial scale due to their complex structures
that often contain several chiral centers. The aim of this study was to test different extracts from the
leaves of Moringa or drumstick tree (Moringa oleifera) for activity against leukemia and
hepatocarcinoma cells in vitro. The extracts could kill majority (70 - 86%) of the abnormal cells among
primary cells harvested from 10 patients with acute lymphoblastic leukemia (ALL) and 15 with acute
myeloid leukemia (AML) as well as a culture of hepatocarcinoma cells (75% death), but most
significantly by the hot water and ethanol extracts. In conclusion, M. oleifera may have potential for use
as source of natural treatment for diseases such as cancer