This paper proposes a cryptography technique based on two dimension 2D chaotic system and DNA sequence. The 2D chaotic map generates two artificial DNA sequences S1and S2 to get a cipher message by encrypting the plain message using the first sequence S1. The sender uses the second sequence S2 to hide the cipher message randomly in a real third sequence S3 that is selected from DNA database. The hamming code approach is applied on the original message M to ensure reliable secret communication. The proposed approach provided a more security method compared to previous approaches.