Two field experiments were carried out at the Research and Experimental Station of the Faculty of Agriculture, Moshtohr, Benha University, Kalubia Governorate during the two summer seasons of 2014 and 2015 to study effect of some weed control treatments and plant densities on two soybean varieties productively and associated weeds. Results of the combined analyses of the two seasons showed that: Pods and seed weights/plant (g), seed, straw and biological yields kg/fad were significantly increased by hand hoeing twice after 15 and 45 days from planting compared with Stomp and Amex.Giza111 soybean variety surpassed Giza 21 in growth characters namely (plant height, dry weight of leaves, stems and plant, while Giza 21 gave the highest value of dry weight of pods. Regarding yield and yield component, Giza 111 recorded the highest value of plant height, straw yield and biological yield, while Giza 21 gave the highest weight of seeds/plant and seed yield/ fad. With regard to plant density Decreasing plant density to 116667plants/fad increased weight of pods and seeds/plant, while the highest plant density (175000 plants/fad) led to increasing the straw and biological yield/ fad. Whereas the plant density 140000 plant/fad recorded the highest values of plant height and seed yield/fad. The interaction between Giza111, plant density of 140000 plants/fad and hand hoeing twice recorded minimum value of dry weight of total weeds at 75 days after planting.