Background: High-mobility
group box 1 (HMGB1)-receptor
for advanced glycation end
(RAGE)-moesin
axis could be implicated in induction of inflammation. However, there
is a scarcity in literature discussing the role of this axis in inflammatory skin disorders.
Aims: The aim of the present study was to evaluate the serum levels of HMGB1 and
moesin in patients with inflammatory acne vulgaris.
Patients/Methods: This comparative cross-sectional
study included 66 inflammatory
acne vulgaris patients classified according to Global Acne Grading System (GAGS) into
three groups (22 patients each): mild, moderate, and severe acne vulgaris. In addition,
82 acne-free
individuals were included as a control group. Serum HMGB 1 and moesin
levels were measured using enzyme-linked
immunosorbent assay kits.
Results: High-mobility
group box 1 and moe sin serum levels in acne patients were
significantly higher than the levels in control subjects (p = 0.04, 0.0005 respectively).
Serum levels of both markers in severe acne patients and in those with post-acne
scarring were elevated when compared to the levels in the other groups, and however,
this elevation was significant only for moesin levels. There was a significant positive
correlation between the serum levels of HMGB1 and moesin in the studied patient's
sample (r = 0.3079, p = 0.011).
Conclusion: High-mobility
group box 1-receptor
for advanced glycation end-moesin
axis may be implicated in acne vulgaris pathogenesis, and it may be a promising therapeutic
target.