Egypt has many wild plants such as Sonchus oleraceus, Cichorium pumilum and Portulacaoleraceae which are one of the perfect sources of natural effective compounds including alkaloids, flavonoids, tannins, terpenes, steroids and phenols. This study investigated that P.oleracea has a greater total phenolic, flavonoids and antioxidant activity followed by S. oleraceus and finally C. pumilum. Also, alkaloid was found in all the plants examined with the highest quantities obtained in S. oleraceus (78.6%) then, P. oleracea (66.4%), while C. pumilum have 41.8%. While total terpenoid and saponin were the highest percentages with Portulaca oleracea (61.6%) and (35.3%) respectively. In addition to all the extracts could inhibit these fungi at a different level in which ethanolic and methanolic extracts of Portulaca oleracea and Cichorium pumilum generally had higher antifungal activities against A. aflatoxiformans and A ochraceus. Finally, these plant extracts contain many effective compounds that enable to play the role of antifungals.