Staff Members - Benha University
ROLE OF ADIPONUTRIN GENE POLYMORPHISM IN DIAGNOSIS OF HCV RELATED HEPATOCELLULAR CARCINOMA (HCC).
Journal of Hepatology, Gastroenterology & Infectious Diseases. JHGID • 2018
Publication Information
Authors
ROLE OF ADIPONUTRIN GENE POLYMORPHISM IN
DIAGNOSIS OF HCV RELATED HEPATOCELLULAR
CARCINOMA (HCC).
Keywords
Adiponutrin; Gene Polymorphism;
chronic HCV; Hepatocellular Carcinoma.
Journal
Journal of Hepatology, Gastroenterology & Infectious Diseases. JHGID
Publisher
Not Available
Volume
16
Issue
1
Pages
1:13.
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
This study evaluates the role of
PNPLA3 gene polymorphism
(rs738409) by PCR/ Taqmanassay in
75chronic HCV patients (50 with
HCC and 25without) and 25 controls.
Thetestedadi ponutrin single
nucleotide polymorphism (SNP)
showed that the C allele of PNPLA3
(rs738409) gene is common in all
groups than G allele and higher in
HCC (95%) than cirrhotic (80%) and
controls (72%). Frequency of HCC
was higher for patients with CC
genotype (90%), than those with CG
(10%) and GG genotype (0%). The
study detected highly statistically
significant difference between HCC
and cirrhotic groups as regard CC
genotype about 4.2 folds (p=0.04)
and C allele (p=0.004).Also, CC
genotype is more prominent in
cirrhotic patients (68%) than controls
group (52%) but difference not
significant.
In Conclusion these results
suggest that PNPLA3 (rs738409)
polymorphism with CC genotype was
significantly associated with liver
cirrhosis and increased risk to
develop, HCC in Egyptian patients
with chronic hepatitis C infection.
PNPLA3 gene polymorphism
(rs738409) by PCR/ Taqmanassay in
75chronic HCV patients (50 with
HCC and 25without) and 25 controls.
Thetestedadi ponutrin single
nucleotide polymorphism (SNP)
showed that the C allele of PNPLA3
(rs738409) gene is common in all
groups than G allele and higher in
HCC (95%) than cirrhotic (80%) and
controls (72%). Frequency of HCC
was higher for patients with CC
genotype (90%), than those with CG
(10%) and GG genotype (0%). The
study detected highly statistically
significant difference between HCC
and cirrhotic groups as regard CC
genotype about 4.2 folds (p=0.04)
and C allele (p=0.004).Also, CC
genotype is more prominent in
cirrhotic patients (68%) than controls
group (52%) but difference not
significant.
In Conclusion these results
suggest that PNPLA3 (rs738409)
polymorphism with CC genotype was
significantly associated with liver
cirrhosis and increased risk to
develop, HCC in Egyptian patients
with chronic hepatitis C infection.