Objective: To assess carbetocin efficacy in terms of mean blood loss in patients undergoing abdominal myomectomy. Material and Methods: The randomised control trial was conducted at the Obstetrics and Gynaecology Department of benha university Hospital, egypt, June 2021, to march 2022, and comprised women with intramural fibroids of American Society of Anaesthesia class I and II who were candidates for elective abdominal myomectomy. The women were randomised into study and control groups. In the study group, an infusion of Carbetocin 100 micrograms/ml. of during surgery. In the control group, pure normal saline was given. The main outcome measure was intra-operative blood loss. Data was analysed using SPSS 21. Results: Of the 60 women, there were 30 (50%) in the study group with a mean age of 37.10 ± 4.35 years, and 30 (50%) in the control group with a mean age of 36.67 ± 3.70 (p>0.05). Mean intra-operative blood loss in the study group was 409.67 ± 181.29 ml which was significantly lower than the control group 875.33±284.71 (p