• Introduction: obesity is a pandemic associated with increased mortality and a lot of morbidities. The aim of this study was to find out the role of affect regulation in cases of adults with obesity. • Patients and Methods: This study was designed to evaluate the cases with obesity, who were diagnosed by using the Body Mass Index (BMI) scale. All the cases and controls completed the Trans Meta Mood Scale (TMMS) and the General Health Questionaire-28 (GHQ-28). • Results: This study included 30 cases of adults with obesity and 30 matched controls with an age range of 18-54 years. The total TMMs scores of the enrolled patients was significantly lower as compared to that of the control subjects, and much higher scores on the GHQ and more prevalence of Significant somatization, anxiety, social dysfunction and depression. • Conclusion: Negative emotional states are related to obesity, and negative affect regulation might be playing a role in obesity. Training to control this negative affect might help in obesity prevention and better outcome in cases of obesity.