Staff Members - Benha University
Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients
• 2013
Publication Information
Authors
Amal S. El-Shala,∗,1, Nader M. Alya, Sahar M. Abdel Galil b, Mohamed A. Moustafac, Wael A. Kandeld
Keywords
Rheumatoid arthritis
MicroRNA
Polymorphism
Egyptian population
Journal
Not Available
Publisher
Not Available
Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Objective: To investigate whether miRNA-499 (rs3746444) and miRNA-146a (rs2910164) genes polymorphisms
are independent factors for rheumatoid arthritis (RA) in Egyptians, and whether they influence
disease severity and activity.
Methods: Two hundred and seventeen RA patients and 245 healthy controls were enrolled in this study.
Polymorphisms of miRNA-146a and miRNA-499 genes were detected using polymerase chain reaction
restriction fragment length polymorphism (PCR-RFLP).
Results: The miRNA-499 CT genotype was an independent factor of RA. The miRNA-499 CT, CC genotypes
and C allele frequencies were significantly increased in erosive RA group. Moreover, the heterozygote CT
had more severe and more active form of the disease compared with homozygote CC or TT. However, we
did not find any significant association of miRNA-146a polymorphism with RA risk, severity, and activity.
Conclusion: The miRNA-499 polymorphism is an independent factor of RA, and influences disease severity
and activity
are independent factors for rheumatoid arthritis (RA) in Egyptians, and whether they influence
disease severity and activity.
Methods: Two hundred and seventeen RA patients and 245 healthy controls were enrolled in this study.
Polymorphisms of miRNA-146a and miRNA-499 genes were detected using polymerase chain reaction
restriction fragment length polymorphism (PCR-RFLP).
Results: The miRNA-499 CT genotype was an independent factor of RA. The miRNA-499 CT, CC genotypes
and C allele frequencies were significantly increased in erosive RA group. Moreover, the heterozygote CT
had more severe and more active form of the disease compared with homozygote CC or TT. However, we
did not find any significant association of miRNA-146a polymorphism with RA risk, severity, and activity.
Conclusion: The miRNA-499 polymorphism is an independent factor of RA, and influences disease severity
and activity