Staff Members - Benha University
Biochemical and Hematological alterations associated with Doxorubicin induced toxicity in Rats
Al-Azhar Bulletin of Science • 2021
Publication Information
Authors
Yakout, A. El-senosi; Samy Ali Hussein; Sayed Bakry and Mariam Thabit
Keywords
Doxorubicin, Hematology, liver functions, kidney functions.
Journal
Al-Azhar Bulletin of Science
Publisher
Al-Azhar University, Faculty of Science (Boys)
Volume
32
Issue
1
Pages
11-16
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: Doxorubicin is an anthracycline drug first extracted from Streptomyces peucetius var. caesius in the 1970’s. It used routinely as highly efficacious drug in many kinds of cancers. But its clinical usefulness is still restricted due to its specific toxicities.
Objective: This study was designed to investigate doxorubicin-induced toxicity in albino rat model.
Materials and Methods: Thirty male young adult Sprague Dawley rats were divided into Three groups. The first served as control group while second and third group treated with 2.5 and 5mg / kg /week. Two hours post DOX administration rats from all the groups were killed , blood samples were drawn for hematological and biochemical changes. Data were analyzed using (SPSS, version 22)
Results:
Hematological parameters obtained from rats treated with Dox revealed that Dox doses induced decrease in RBCs Count, Hemoglobin (Hb) concentration and HCT % when compared with the corresponding values of control rats. Otherwise, WBC.s differential count including (lymphocyte, monocyte , neutrophil , monocyte as well as neutrophil) and platelets count showed a significant decrease (P
Objective: This study was designed to investigate doxorubicin-induced toxicity in albino rat model.
Materials and Methods: Thirty male young adult Sprague Dawley rats were divided into Three groups. The first served as control group while second and third group treated with 2.5 and 5mg / kg /week. Two hours post DOX administration rats from all the groups were killed , blood samples were drawn for hematological and biochemical changes. Data were analyzed using (SPSS, version 22)
Results:
Hematological parameters obtained from rats treated with Dox revealed that Dox doses induced decrease in RBCs Count, Hemoglobin (Hb) concentration and HCT % when compared with the corresponding values of control rats. Otherwise, WBC.s differential count including (lymphocyte, monocyte , neutrophil , monocyte as well as neutrophil) and platelets count showed a significant decrease (P