Staff Members - Benha University
Effect of probiotic fermented soy milk and gamma radiation in ameliorating oxidative stress and apoptosis on nitrosoureainduced mammary carcinogenesis
Lucrări Ştiinţifice USAMV Iaşi – seria Medicină Veterinară • 2014
Publication Information
Authors
Omayma A. Ragab, Amira E. Aboelftouh El-Sonbaty, S. M.,Aziza S. A.(
Keywords
fermented soy, N-methyl-N-nitrosourea, mammary gland, cell cycle, TNF- α, gamma
radiation, antioxidant state.
Journal
Lucrări Ştiinţifice USAMV Iaşi – seria Medicină Veterinară
Publisher
UNIVERSITATEA DE ŞTIINŢE AGRICOLE ŞI MEDICINĂ VETERINARĂ ʺION IONESCU DE LA BRADʺ IAŞI – ROMÂNIA
Volume
57
Issue
nr. 3-4
Pages
55-66
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background and aim of the work: Antioxidants can reduce damage produced by low doses of radiation
on living cells. This study was designed to investigate the effects of fermented soy milk (FSM) and low dose of
gamma radiation on carcinogenic effect of N-methyl-N-nitrosourea (MNU). Materials and methods: Female rats
were divided into 8 groups: group (1): control, group (2): injected with MNU, group (3): whole body exposed to
low dose of gamma radiation (0.5 Gy), group (4): given FSM orally, group (5): given FSM and MNU, group (6):
received FSM and exposed to gamma radiation, group (7): given FSM, MNU and exposed to gamma radiation.
Results: Fermented soy milk exerted significant, ameliorative effect on glutathione peroxidase, superoxide
dismutase and catalase activities, lipid peroxidation and TNF-α level and lipid profiles in rats injected with MNU.
Combined treatment of FSM and low dose of gamma radiation markedly elevated GSH level, ameliorated MNU
effect on cell cycle phases Go/1, S, G2/M and induce apoptosis via activation of caspase-3. Conclusion: FSM
consumption with exposure to low doses of gamma radiation reduced carcinogenesis and oxidative stress effects
induced by MNU in the mammary tissues.
on living cells. This study was designed to investigate the effects of fermented soy milk (FSM) and low dose of
gamma radiation on carcinogenic effect of N-methyl-N-nitrosourea (MNU). Materials and methods: Female rats
were divided into 8 groups: group (1): control, group (2): injected with MNU, group (3): whole body exposed to
low dose of gamma radiation (0.5 Gy), group (4): given FSM orally, group (5): given FSM and MNU, group (6):
received FSM and exposed to gamma radiation, group (7): given FSM, MNU and exposed to gamma radiation.
Results: Fermented soy milk exerted significant, ameliorative effect on glutathione peroxidase, superoxide
dismutase and catalase activities, lipid peroxidation and TNF-α level and lipid profiles in rats injected with MNU.
Combined treatment of FSM and low dose of gamma radiation markedly elevated GSH level, ameliorated MNU
effect on cell cycle phases Go/1, S, G2/M and induce apoptosis via activation of caspase-3. Conclusion: FSM
consumption with exposure to low doses of gamma radiation reduced carcinogenesis and oxidative stress effects
induced by MNU in the mammary tissues.