Staff Members - Benha University
Synthesis and Characterization of Nano-doped Zinc Oxide and its Application as Protective Oxidative Changes in the Retina of Diabetic Rats
Journal of Diabetes & Metabolism • 2016
Publication Information
Authors
Soheir N Abd El-Rahman, SM Reda and Sheikha M AlGhannam
Keywords
Nano-doped zinc oxide; Oxidative stress; F:ZnO;
Cl:ZnO; Diabetic retinopathy
Journal
Journal of Diabetes & Metabolism
Publisher
OMICS International
Volume
7
Issue
7
Pages
2-6
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Oxidative stress is a basic mechanism behind the development of diabetic retinopathy (DR). Therefore, the
present study conducted to evaluate the protective effect of zinc oxide nanoparticles (ZnONPs) doped with fluorine
(F:ZnO) and chlorine (Cl:ZnO), on retinal oxidative stress in type II diabetic rats. TEM showed that the F:ZnO and
Cl:ZnO have average particle size 17.7 and 59.3 nm, respectively. The results indicated that serum glucose was
increased significantly (p ≤ 0.05) and serum insulin was decreased significantly 3 days after treatment with STZ
compared to other groups. STZ treatment depleted both retinal and liver TBA and retinal GST contents. While,
simultaneous treatment rats with low and high dose of STZ + F:ZnO and STZ + Cl:ZnO were decreased serum
glucose induced by STZ and reversed the deplete influence on GSH level of retinal and reduced the highs in TBA
levels of livers and retinas in STZ -administrated rats. The results investigate the useful effects of high dose of F:ZnO
and Cl:ZnO in protection diabetic rats against hyperglycemia and retina against oxidative stress.
present study conducted to evaluate the protective effect of zinc oxide nanoparticles (ZnONPs) doped with fluorine
(F:ZnO) and chlorine (Cl:ZnO), on retinal oxidative stress in type II diabetic rats. TEM showed that the F:ZnO and
Cl:ZnO have average particle size 17.7 and 59.3 nm, respectively. The results indicated that serum glucose was
increased significantly (p ≤ 0.05) and serum insulin was decreased significantly 3 days after treatment with STZ
compared to other groups. STZ treatment depleted both retinal and liver TBA and retinal GST contents. While,
simultaneous treatment rats with low and high dose of STZ + F:ZnO and STZ + Cl:ZnO were decreased serum
glucose induced by STZ and reversed the deplete influence on GSH level of retinal and reduced the highs in TBA
levels of livers and retinas in STZ -administrated rats. The results investigate the useful effects of high dose of F:ZnO
and Cl:ZnO in protection diabetic rats against hyperglycemia and retina against oxidative stress.