Staff Members - Benha University
Serum TWEAK in acne vulgaris: An unknown soldier
Journal of Cosmetic Dermatology • 2019
Publication Information
Authors
El-Taweel AEI1, Salem RM1, Abdelrahman AMN2, Mohamed BAE3.
Keywords
TWEAK; acne; inflammation
Journal
Journal of Cosmetic Dermatology
Publisher
Wiley Periodicals, Inc.
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Abstract
BACKGROUND:
TWEAK is an inflammatory cytokine which is involved in the development of many inflammatory disorders.
AIMS:
This study aimed to evaluate serum levels of TWEAK in patients with acne vulgaris.
SUBJECTS AND METHODS:
This case-controlled study included 100 acne vulgaris patients divided into two groups. Group 1 included 25 patients with moderate acne and 25 patients with severe acne. Group 2 consisted of 50 acne-free control subjects. Acne was graded by the Global Acne Grading System (GAGS). Serum TWEAK was measured by ELISA kits.
RESULTS:
Acne patients had significant elevation in TWEAK serum levels when compared to the control subjects (P < 0.001). TWEAK serum levels did not show significant difference regarding disease grade, postacne scar, and hyperpigmentation (P value = 0.43, 0.37, 0.80, 0.67, respectively). TWEAK levels were not affected by any of the studied variables except for the significant negative correlation between its levels and the disease duration in severe acne group only (r = -0.42, P = 0.03).
CONCLUSION:
TWEAK may be involved in acne vulgaris development, but more studies are needed to clarify its role.
© 2019 Wiley Periodicals, Inc.
BACKGROUND:
TWEAK is an inflammatory cytokine which is involved in the development of many inflammatory disorders.
AIMS:
This study aimed to evaluate serum levels of TWEAK in patients with acne vulgaris.
SUBJECTS AND METHODS:
This case-controlled study included 100 acne vulgaris patients divided into two groups. Group 1 included 25 patients with moderate acne and 25 patients with severe acne. Group 2 consisted of 50 acne-free control subjects. Acne was graded by the Global Acne Grading System (GAGS). Serum TWEAK was measured by ELISA kits.
RESULTS:
Acne patients had significant elevation in TWEAK serum levels when compared to the control subjects (P < 0.001). TWEAK serum levels did not show significant difference regarding disease grade, postacne scar, and hyperpigmentation (P value = 0.43, 0.37, 0.80, 0.67, respectively). TWEAK levels were not affected by any of the studied variables except for the significant negative correlation between its levels and the disease duration in severe acne group only (r = -0.42, P = 0.03).
CONCLUSION:
TWEAK may be involved in acne vulgaris development, but more studies are needed to clarify its role.
© 2019 Wiley Periodicals, Inc.