Staff Members - Benha University
Assessment of ERBB2 protein expression and gene amplification in urothelial bladder carcinoma by immunohistochemistry and fluorescence in situ hybridization
Egyptian Journal of Pathology • 2016
Publication Information
Authors
Ahlam A. Abd ElMaksoud, Nashwa M Emara, Ranih Z Amer
Keywords
Not Available
Journal
Egyptian Journal of Pathology
Publisher
Wolters Kluwer, Lippincott Williams & Wilkins
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: The goal of this study was to investigate ERBB2 (HER2) gene amplification and protein expression in bladder urothelial carcinoma. The HER2 status of 40 patients with transurethral resection or cystectomy was investigated. All cases were analyzed for both HER2 overexpression using immunohistochemistry and HER2 gene amplification using fluorescence in situ hybridization. Eighteen cases had a HER2 score-0 or score-1 (45%), 10 cases had a score-2 (25 %), and 12 cases had a score-3 (30%) with immunohistochemistry. HER2 gene amplification was observed in 16 out of 40 cases (40%). HER2 overexpression and gene amplification were correlated to a high histological grade (P< 0.0001), stage (P