Staff Members - Benha University
THE POSSIBLE PROTECTIVE ROLE OF CANDISARTAN ON CYCLOSPORINE INDUCED NEPHROTOXICITY IN RATS
• 2013
Publication Information
Authors
Abeer A. Shoman M.D.3 and Noha. I. Hussein M.D3 Hanan T. Emam M.D.1, Abd El Moneim G. Madbouly M.D.2
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publication.type
International
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Abstract
Cyclosporine A (CsA), a fungal undecapeptide, is the most common
immunosuppressive drug used in organ trans-plantation and autoimmune diseases.
However, nephrotoxicity is the major adverse effect of CsA use. The molecular mech-anisms
of CsA nephrotoxicity are not well characterized, but more recent studies suggest an
involvement of angiotensin 11 (ANG II) and reactive oxygen species in the development of
cyclosporine nephrotoxicity. This study was thus designed to investigate the role of ...
immunosuppressive drug used in organ trans-plantation and autoimmune diseases.
However, nephrotoxicity is the major adverse effect of CsA use. The molecular mech-anisms
of CsA nephrotoxicity are not well characterized, but more recent studies suggest an
involvement of angiotensin 11 (ANG II) and reactive oxygen species in the development of
cyclosporine nephrotoxicity. This study was thus designed to investigate the role of ...