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Synthesis of 3-(phenoxathiin-2-yl)-2-pyrazoline derivatives as new antibacterial and antifungal agents

Journal of Sulfur Chemistry • 2010
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Publication Information
Authors Mohamed S. Behalo
Keywords phenoxathiin; pyrazoline; thiazole; antimicrobial activity
Journal Journal of Sulfur Chemistry
Publisher TTaylor & Francis
Volume 31
Issue 4
Pages 287–297
publication.type International
Paper Link Not Available
Supplementary Materials Not Available
Abstract
A new series of 3-(phenoxathiin-2-yl)-5-aryl-2-pyrazoline derivatives were synthesized from the reaction
of 1-(phenoxathiin-2-yl)-3-phenyl/(4-chlorophenyl)propenones 1a and 1b with different nitrogen nucleophiles.
The titled compounds were investigated for their antibacterial and antifungal activities and were
compared with the standard drugs. Most of the synthesized compounds demonstrated potent to weak
antimicrobial activity.