Staff Members - Benha University
TelomeraseActivityinDiabeticPatientswithAngiopathy
LifeScienceJournal2014;]1(4) • 2014
Publication Information
Authors
AymanElBadawy,
Keywords
telomerase,diabeticpatients,angiopathy(micro-ormacroangiopathy).
Journal
LifeScienceJournal2014;]1(4)
Publisher
Not Available
Volume
14
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Diabetesmellitus(DM)is associatedwithdamagetotargetorgansandprematureaging
andtelomeresserveas amitoticclockandbiologicalmarkerofsenescence.Aimofstudy:wastoA)evaluate
telomeraseactivity in bothtype i andtype2diabeticpatientswithmicroangiopathyandmacroangiopathy, B)to
studythepossiblefactorsthataffecttheactivityofthisenzymeinthesepatients.SubjectsandMethods:Studywas
carriedouton40patientsfromthoseattendingdiabetesclinicsofBanhaUniversityHospital,theyweredividedinto
three groups:GroupI: 10type I diabeticpatientswithangiopathy(4males&6females).GroupII: l0type 2
diabetic patients withangiopathy(3males&7females). GroupIII: 20apparentlyhealthyage&sexmatched
volunteers serving as a control group.Thefollowing laboratory investigations wereperformed to all patients:
Plasmaglucose(fastingandpostprandial),Glycatedhemoglobin,Lipogram(Total cholesterol,LDLc,I-[DLcand
Triglycerides),Serumcreatinine,UrinarymicroalbuminandStudyoftelomeraseactivityinwholeblood.Results:
Ourresults showed: that (HBAIC,microalbumin, creatinine, LDL,TG,TCH,PPBSandFBS)aresignificantly
higherindiabeticpatientscomparedtocontrolgroupwhere(telomeraseandHDL)aresignificantlylowerindiabetic
patientscomparedtocontrolgroup.Also,TelomeraseactivitywassignificantlylowindiabeticpatientswithI-ll:AlC
(27%). LDL-c (>l0Omg/dl), HDL-c (l50mg/dl), TCH (>200mg/dl), microalbuminuria
(>30mg/ml) respectively compared to diabetic patients with I-IbAlC (
andtelomeresserveas amitoticclockandbiologicalmarkerofsenescence.Aimofstudy:wastoA)evaluate
telomeraseactivity in bothtype i andtype2diabeticpatientswithmicroangiopathyandmacroangiopathy, B)to
studythepossiblefactorsthataffecttheactivityofthisenzymeinthesepatients.SubjectsandMethods:Studywas
carriedouton40patientsfromthoseattendingdiabetesclinicsofBanhaUniversityHospital,theyweredividedinto
three groups:GroupI: 10type I diabeticpatientswithangiopathy(4males&6females).GroupII: l0type 2
diabetic patients withangiopathy(3males&7females). GroupIII: 20apparentlyhealthyage&sexmatched
volunteers serving as a control group.Thefollowing laboratory investigations wereperformed to all patients:
Plasmaglucose(fastingandpostprandial),Glycatedhemoglobin,Lipogram(Total cholesterol,LDLc,I-[DLcand
Triglycerides),Serumcreatinine,UrinarymicroalbuminandStudyoftelomeraseactivityinwholeblood.Results:
Ourresults showed: that (HBAIC,microalbumin, creatinine, LDL,TG,TCH,PPBSandFBS)aresignificantly
higherindiabeticpatientscomparedtocontrolgroupwhere(telomeraseandHDL)aresignificantlylowerindiabetic
patientscomparedtocontrolgroup.Also,TelomeraseactivitywassignificantlylowindiabeticpatientswithI-ll:AlC
(27%). LDL-c (>l0Omg/dl), HDL-c (l50mg/dl), TCH (>200mg/dl), microalbuminuria
(>30mg/ml) respectively compared to diabetic patients with I-IbAlC (