Staff Members - Benha University
STUDY OF IRON STATUS PARAMETERS AND SERUM ALUMINUM LEVEL IN PATIENTS WITH CHRONIC RENAL FAILURE .EFFECT OF RECOMBINANT HUMAN ERYTHROPOIETN IN AND OTHER MODALITIES OF TREATMENT
BenhaM.J. • 1997
Publication Information
Authors
InasEl-ShaarawyMD.MohamedShawkyMD*,SoberAbdEl-RahmanMD,MohamedEl-HendyMDandSherifNigmMD*
Keywords
Not Available
Journal
BenhaM.J.
Publisher
Not Available
Volume
Vol. 14N02May1997
Issue
Not Available
Pages
347-361
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Thisstudywasconductedonfifiyuremicpatientsunderregularhaemodialysisand10healthycontrolsubjectsinordertostudytheparametersofironstatusandserumaluminuminthesepatients,andtoellucidatetheefiectofdifferentmodalitiesoftreatmentontheanemia,iron
statusparametersandserumaluminum,
Theuremicpatientswereclassifiedintofivegroups,eachincluded10 i
patients:groupIpatientsdidn'treceivetreatment,group11patientswas
givenTHLLEPO.groupIIIpatientswasgivenoraliron,groupIVpatientsreceivedcorrdvinedEPOandiron,whereasgroupVpatientsreceiveddesferroxamine.Thedurationoftreatmentwas6months.Thefollowinginvestigations, were performed before and after treatment: complete
bloodpicture,bloodurea,serumcreatinine,serumferritin,serumiron,total
ironbindingcapacity,ironbindingsaturation,serumaluminumandbone E
marrow(B.M)biopsy.
Ourstudyshowedthatanemiawasauniversalfindinginalluremic
patients60%hadmicrocytichypochromicand40%hadnormocyticnormochromicanemia.
SerumFe,TIBC,IBSandBMironstorageweresignificantlylowin
uremicpatients,whereasserumferritinandserumaluminumlevelswere
significantlyhighinthesepatients.
statusparametersandserumaluminum,
Theuremicpatientswereclassifiedintofivegroups,eachincluded10 i
patients:groupIpatientsdidn'treceivetreatment,group11patientswas
givenTHLLEPO.groupIIIpatientswasgivenoraliron,groupIVpatientsreceivedcorrdvinedEPOandiron,whereasgroupVpatientsreceiveddesferroxamine.Thedurationoftreatmentwas6months.Thefollowinginvestigations, were performed before and after treatment: complete
bloodpicture,bloodurea,serumcreatinine,serumferritin,serumiron,total
ironbindingcapacity,ironbindingsaturation,serumaluminumandbone E
marrow(B.M)biopsy.
Ourstudyshowedthatanemiawasauniversalfindinginalluremic
patients60%hadmicrocytichypochromicand40%hadnormocyticnormochromicanemia.
SerumFe,TIBC,IBSandBMironstorageweresignificantlylowin
uremicpatients,whereasserumferritinandserumaluminumlevelswere
significantlyhighinthesepatients.