Staff Members - Benha University
Effects of Triclocarban on Intact Immature Male Rat: Augmentation of Androgen Action
• 2011
Publication Information
Authors
Antoni J. Duleba, MD1, Mohamed I. Ahmed, MD2, Meng Sun, PhD3,
Allen C. Gao, MD, PhD3, Jesus Villanueva, DVM, PhD1,
Alan J. Conley, DVM, PhD4, Judith L. Turgeon, PhD5,
Kurt Benirschke, MD6, Nancy A. Gee, BS7, Jiangang Chen, PhD7,
Peter G. Green, PhD8,
Keywords
triclocarban, androgen receptor, luteinizing hormone, testosterone, endocrine-disrupting substance
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Triclocarban (TCC; 3,4,40-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products
including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex
organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on
human prostate LNCaP and C4–2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented
with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant
qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC
treatment. In prostate cancer-derived LNCaP and C4–2B cells, TCC potentiated androgen actions via androgen receptordependent
actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in
prostate cancer cells.
including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex
organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on
human prostate LNCaP and C4–2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented
with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant
qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC
treatment. In prostate cancer-derived LNCaP and C4–2B cells, TCC potentiated androgen actions via androgen receptordependent
actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in
prostate cancer cells.