Staff Members - Benha University
Biochemical Effect of Experimental Hepatic Failure in Tissues Antioxidants in Aging Rats
BENHA VETERINARY MEDICAL JOURNAL • 2015
Publication Information
Authors
Hussein Abd El - Maksoud1; Usama Mahrous 2; Qadri Mohammed Sadik 3 and Yaser M. Abdel –
Nabi 3
Keywords
Hepatic failure, Thioacetamide and tissues antioxidants.
Journal
BENHA VETERINARY MEDICAL JOURNAL
Publisher
BENHA VETERINARY MEDICAL JOURNAL
Volume
29
Issue
NO. 2
Pages
161-169
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
The present study aimed to trigger the effect of experimentally induced chronic hepatic failure on tissues
antioxidant status in different ages the hepatic failure induced by Intraperitoneal administration of
Thioacetamide at a dose of (30 - mg/kg body weight) four times through two months with 15 days
interval Rats were sacrificed 24 hrs after the last dose of TAA the recorded data revealed significant
decrease in Brain tissue Monoaminooxidase (MAO) and significant increase in brain tissue nitric oxide
(NO) and ammonia, significant decrease in Brain, kidney, muscles and hepatic tissues Reduced
Glutathione (GSH) Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) from the recorded
results it could be concluded that hepatic failure is a hazard stress in tissues antioxidants in different
ages
antioxidant status in different ages the hepatic failure induced by Intraperitoneal administration of
Thioacetamide at a dose of (30 - mg/kg body weight) four times through two months with 15 days
interval Rats were sacrificed 24 hrs after the last dose of TAA the recorded data revealed significant
decrease in Brain tissue Monoaminooxidase (MAO) and significant increase in brain tissue nitric oxide
(NO) and ammonia, significant decrease in Brain, kidney, muscles and hepatic tissues Reduced
Glutathione (GSH) Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) from the recorded
results it could be concluded that hepatic failure is a hazard stress in tissues antioxidants in different
ages