Staff Members - Benha University
Comparative Effects of Purslane seed oil (PSO) and 5- Flourourasil on Ehrlich ascites carcinoma (EAC) in female albino mice
Intternattiionall Journall of Pharma Sciiences • 2014
Publication Information
Authors
Hussein A. Ali1, Mohammed A. Hussein2,*, Walaa E. Mohammed1
Keywords
Purslane seed oil (PSO), 5-Flourourasil, breast cancer, Ehrlich ascites cells and antioxidants
Journal
Intternattiionall Journall of Pharma Sciiences
Publisher
aizeon publisher
Volume
Vol. 4
Issue
No. 1 (2014)
Pages
424-430
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
The present study was to evaluate anti-cancer effects of Purslane seed oil (PSO) (200g/kg. diet), 5-Flourourasil
(20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21
consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, PSO was supplemented
at (200g/kg. diet) daily for 21 consecutive days. On the 22th day, the mice were sacrificed for the estimation of tumor
growth (tumor volume), and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate
transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein
thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total
cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone). The results of this study also
showed that administration of Purslane seed oil (PSO), 5-Flourourasil both individually and in combination for 21
days to the carcinoma induced mice demonstrated a significant (P
(20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21
consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, PSO was supplemented
at (200g/kg. diet) daily for 21 consecutive days. On the 22th day, the mice were sacrificed for the estimation of tumor
growth (tumor volume), and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate
transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein
thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total
cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone). The results of this study also
showed that administration of Purslane seed oil (PSO), 5-Flourourasil both individually and in combination for 21
days to the carcinoma induced mice demonstrated a significant (P