Staff Members - Benha University
Potential Therapeutic activity of Novel Nanocomposite on Cancerous Tumor Bearing Mice
Intternattiionall Journall of Pharma Sciiences • 2016
Publication Information
Authors
Omayma A.R. Abou Zaid1, AbdEl Maksoud Hussein A.1, Abdel Fatah M. Badwi2, Mohammed F. EL-Shiekha1 and Mohammed Abdalla Hussien3*
Keywords
Curcumin nanoparticles, Zinc Oxide nanoparticles (ZnNP), Vitamin C, CTAB, (p53- gene expression), Apoptosis.
Journal
Intternattiionall Journall of Pharma Sciiences
Publisher
aizeon publisher
Volume
Vol. 6
Issue
No. 3 (2016)
Pages
1580-1586
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
ABSTRACT
Nanoparticles are making significant contributions to the development of new approaches of drug delivery in cancer and can provide a platform for combined therapeutics with subsequent monitoring of response. Basic curcumin and zinc oxide (ZnO) Nanocomposite modified with vitamin C and CTAB have been exerting chemopreventative activity against cancer in mice animal model. The present results observed that Nanocomposite have distinct effects on liver cell viability via killing cancer cells, while posing no effect on normal cells (hepatocytes). The marked difference in cytotoxicity between cancer cells and normal cells suggests an exciting potential for Nanocomposite as novel alternatives to cancer therapy. Our molecular data showed that both mRNA and protein levels of tumor suppressor gene p53 were upregulated and induce activity of DNA fragmentation in liver cells.
Nanoparticles are making significant contributions to the development of new approaches of drug delivery in cancer and can provide a platform for combined therapeutics with subsequent monitoring of response. Basic curcumin and zinc oxide (ZnO) Nanocomposite modified with vitamin C and CTAB have been exerting chemopreventative activity against cancer in mice animal model. The present results observed that Nanocomposite have distinct effects on liver cell viability via killing cancer cells, while posing no effect on normal cells (hepatocytes). The marked difference in cytotoxicity between cancer cells and normal cells suggests an exciting potential for Nanocomposite as novel alternatives to cancer therapy. Our molecular data showed that both mRNA and protein levels of tumor suppressor gene p53 were upregulated and induce activity of DNA fragmentation in liver cells.