Staff Members - Benha University
EVALUATION OF AN INACTIVATED COMBINED OIL VACCINE PREPARED FOR FOOT AND MOUTH DISEASE AND BOVINE EPHEMERAL FEVER VIRUSES.
BENHA VETERINARY MEDICAL JOURNAL • 2014
Publication Information
Authors
GF El-Bagoury; AS El-Habbaa; MA Gamil; HG Fawzy
Keywords
FMDV, BEFV, Combined vaccine
Journal
BENHA VETERINARY MEDICAL JOURNAL
Publisher
BENHA VETERINARY MEDICAL JOURNAL
Volume
27
Issue
No. 1
Pages
221‐231
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Vaccination programs using FMD virus and BEF virus vaccines were effective for the disease control but
the repeated vaccination induces stress on animals with increased cost of vaccination for the farmer. The
present study aimed to prepare an inactivated combined vaccine containing three FMD virus serotypes O,
A, SAT2 and BEF antigens adjuvant with Montanide oil ISA 206. The prepared vaccine proved to be sterile
and safe and induced humoral immune response in calves after single dose administration. Serum neutralizing antibody reached the protective titers at 3rd week post vaccination for FMD virus serotypes O, A and SAT2 and at 2nd week post vaccination for BEF virus. Serum neutralizing antibody maintained at the protective titers for up to 32 and 42 weeks post vaccination for FMD and BEF viruses, respectively without inducing any adverse reactions. In conclusion, animals could be safely vaccinated with combined
inactivated FMD and BEF viruses vaccine without impairing the immune response against these antigens
the repeated vaccination induces stress on animals with increased cost of vaccination for the farmer. The
present study aimed to prepare an inactivated combined vaccine containing three FMD virus serotypes O,
A, SAT2 and BEF antigens adjuvant with Montanide oil ISA 206. The prepared vaccine proved to be sterile
and safe and induced humoral immune response in calves after single dose administration. Serum neutralizing antibody reached the protective titers at 3rd week post vaccination for FMD virus serotypes O, A and SAT2 and at 2nd week post vaccination for BEF virus. Serum neutralizing antibody maintained at the protective titers for up to 32 and 42 weeks post vaccination for FMD and BEF viruses, respectively without inducing any adverse reactions. In conclusion, animals could be safely vaccinated with combined
inactivated FMD and BEF viruses vaccine without impairing the immune response against these antigens