Staff Members - Benha University
Mannose-Binding Lectin and Susceptibility to Schistosomiasis
• 2012
Publication Information
Authors
Justin S. Antony,1,a Olusola Ojurongbe,1,2,a Hoang van Tong,1 Eman Abou Ouf,1 Thomas Engleitner,1 Akeem A. Akindele,2Olawumi R. Sina-Agbaje,3 Adegboyega O. Adeyeba,2 Peter G. Kremsner,1 and Thirumalaisamy P. Velavan1
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publication.type
International
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Abstract
Background. Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to
specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and
are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants
and ficolin-2 serum levels as protective factors against schistosomiasis.
Methods. We used the Nigerian cohort from our recently published study, which included 163 Schistosoma
haematobium–infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and
MBL2 polymorphisms are associated with schistosomiasis.
Results. MBL serum levels were significantly higher in controls and were associated with protection (P < .0001).
The −550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes
−550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with
protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion
in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
Conclusions. In agreement with findings from our recently published study, the findings reported here support
the observation that MBL is also associated with protection in schistosomiasis.
Keywords. MBL2; genotypes; haplotypes; serum level; Schistosomiasis
specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and
are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants
and ficolin-2 serum levels as protective factors against schistosomiasis.
Methods. We used the Nigerian cohort from our recently published study, which included 163 Schistosoma
haematobium–infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and
MBL2 polymorphisms are associated with schistosomiasis.
Results. MBL serum levels were significantly higher in controls and were associated with protection (P < .0001).
The −550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes
−550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with
protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion
in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
Conclusions. In agreement with findings from our recently published study, the findings reported here support
the observation that MBL is also associated with protection in schistosomiasis.
Keywords. MBL2; genotypes; haplotypes; serum level; Schistosomiasis