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Role of Interleukin 1β in Colostral Breast milk and Neonatal Hyperbilibinemia

• 2014
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Publication Information
Authors Doaa Refaey Soliman, MD*, Deena A. Elshabrawy MD**, AlRawhaa A. Abo-Aamer M.D.*, Azza SM Hafez MSc.*
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publication.type Local
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Abstract
Physiological jaundice is common in breastfed babies and is attributed to inadequate breastfeeding. However the mechanism underlying its pathogenesis is not clear.
Aim: To investigate the possible relationship between neonatal jaundice and levels of interleukin I β in the colostrum of their nursing mothers.
Methodology: Blood samples from 60 neonates were drawn for the measurement of total serum bilirubin (TSB) with simultaneous expression of colostrum samples from their mother for measuring Interleukin-1β and full clinical assessment of the pair.
Findings: Level of IL1β in breast milk was significantly higher in the group with neonatal jaundice and was positively correlated with TSB levels and mother age at P