This paper aimed to study the susceptibility of quail to infection with pigeon paramyxovirus type-1 (PPMV-1) and their possible role for hazard spread of infection to pigeons. Quail showed high resistance to infection with PPMV-1 with mild clinical signs started by the 10th day post infection detected in 4 out of 20 qail and
represented by dullness, ruffled feather, diarrhea and weakness but no nervous signs were observed. Recovery occurred to most of infected quail (19 out of 20) after 3 weeks post infection and one was died. In contact pigeons showed classical signs of PPMV-1 infection represented by greenish diarrhea, weakness and nervous signs. The morbidity and mortality rates were 20% and 5% respectively in quail and 25% and 20% respectively among in contact pigeons. PM lesion of died pigeons and quail showed congestion of internal organs with PPMV-1 was recovered from liver, spleen and kidneys of dead birds. Survived quail
exhibited detectable HI and SNT antibody titers by the 1st week post infection. Vaccination of quail with the inactivated PPMV-1 vaccine resulted in good immune response of high antibody levels up to 10 weeks post vaccination although such levels were found to be lower than those induced by the same vaccine in pigeons.