Staff Members - Benha University
High Plasma Retinol-Binding Protein-4 Level is Associated with Impaired Glucose Metabolism in Obese Subjects.
British Journal of Science • 2013
Publication Information
Authors
Mohamed Awad,Ashraf Talaat, El said el nahal, Mohamed Fawzy
Keywords
Adipokines, RBP4, Insulin resistance, HOMA-IR, HOMA-B and Type 2 DM.
Journal
British Journal of Science
Publisher
British Journal of Science
Volume
9
Issue
2047-3745
Pages
51 - 66
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background:Retinol-binding protein 4 (RBP4) is a novel adipokine that induces insulin
resistance in mice.Objective: Measurement of serum RBP4 concentration and relationship to
insulin sensitivity and secretion in obese subjects with dysglycemia.Design and
Participants: This case-control study consisted of 100 subjects, 20 of them were healthy lean
subjects and 80 obese patients .They were divided into three groups : normal glucose
tolerance (NGT; n = 20), impaired glucose tolerance (IGT; n = 20), and type 2 diabetes (n =
40). Laboratory and anthropometric measurements including, serum RBP4 levels, were
assessed.RESULTS: Plasma RBP4 levels were higher in obese IGT and T2DM subjects
compared with obese NGT subjects (23.7+10, 26.3+10 vs. 16.64+8 +g/ml, P
resistance in mice.Objective: Measurement of serum RBP4 concentration and relationship to
insulin sensitivity and secretion in obese subjects with dysglycemia.Design and
Participants: This case-control study consisted of 100 subjects, 20 of them were healthy lean
subjects and 80 obese patients .They were divided into three groups : normal glucose
tolerance (NGT; n = 20), impaired glucose tolerance (IGT; n = 20), and type 2 diabetes (n =
40). Laboratory and anthropometric measurements including, serum RBP4 levels, were
assessed.RESULTS: Plasma RBP4 levels were higher in obese IGT and T2DM subjects
compared with obese NGT subjects (23.7+10, 26.3+10 vs. 16.64+8 +g/ml, P