Hyperlipidemia and atherosclerosis are among major health risk concerns. The aim of the present study
was to evaluate the possible improving potentials of Moringa oleifera extract (MOE), in hydroethanol 30%, on lipid
metabolic profile in hyperlipidemic rat model. Rats were rendered hyperlipidemic by 6-week supplementation of
high-fat diet ad libitum. Rats were assigned into six groups; with different treatments (group-1 received normal diet
and kept as normal control; group-2 were fed high-fat (cholesterol 2% + coconut oil 2%) diet for 6 weeks and kept
as diseased control; group-3 were kept on high-fat diet but received ezetimibe (1 mg/Kg, orally, daily) and kept as
standard; while rats of groups-4, -5 and -6 were kept on high-fat diet and received MOE at doses of 200, 400 and
600 mg/Kg, orally, daily, and kept as treated groups. Blood samples for serum were taken for clinicochemical
analysis on the days 21 (3 weeks) and 42 (6 weeks) of the experiment and tissue specimens from the aorta were
taken for histopathology. MOE extract significantly (P