Correction of metabolic acidosis (MA) by using oral sodium bicarbonate therapy (OSBT) in non-dialysis dependent chronic kidney disease (CKD) patients with MA has a positive effect on myocardium as it improves the functional parameters and delay worsening of the structural parameters through modification of risk factors as correction of MA leads to increase of eGFR, decrease of uremia, decrease of serum uric acid level, better control of DM, improvement of lipid profile, thyroid profile and malnutrition inflammation complex syndrome (MICS). Aim of the work: To assess the association between myocardial injury and MA in non-dialysis dependent CKD patients and the impact of the correction of MA on myocardium. Patient and Methods: The study was carried out at nephrology unit, internal medicine department, at Banha University Hospitals on 6 months' duration, where 50 patients were selected. Echocardiography, arterial blood gases, anion gap, e GFR, serum uric acid, lipid profile, urine analysis, troponin I, CK-MB, serum creatinine, HA1C, serum albumin and CRP were measured before and after OSBT. Results: Mean blood PH statistically significant increased from 7.26±0.03 to 7.35±0.003 (p value < 0.001). Mean serum HCO3¯ statistically significant increased from 13.65±1.19 to 23.56±0.74 (p value < 0.001). Mean LVESD statistically significant decreased from 3.86±0.47 to 3.78±0.54 cm (p value 0.035). Mean LVESD no statistically significant difference from 5.62±0.43 to 5.63±0.42 (p value 0.76). Mean EF% statistically significant increased from 52 to 57 % (p value < 0.001). Conclusion: OSBT has a positive effect on myocardium by improvement of the functional parameters and delay worsening of the structural parameters.