This study was carried out on 500 genitalia of slaughtered she camels collected from Benha and Toukh abattoirs, Kaluobia governorate to identify the incidence of pathological affections and describe both gross and microscopic pictures of each one. One hundred and thirty cases of different pathological conditions were recorded with an incidence of 26%. According to the histopathological examination, these affections were classified into ovarian affections (10.4 %), oviductal affections (2.8 %), uterine affections (13.2 %), cervical affections (0.4 %) and vaginal affections (1.4 %). Cystic ovaries were the commonest ovarian lesions. Follicular cysts, hemorrhagic cysts, luteal cysts, dermoid cysts and paraovarian cysts were detected. In addition, two cases of hypoplastic ovary and one case of arrhenoblastoma were also recorded. The uterine pathological conditions were mostly inflammatory in nature and represented by acute catarrhal endometritis, chronic catarrhal endometritis, acute haemorrhagic endometritis, suppurative endometritis and chronic cystic endometritis. Moreover, 5 cases of uterine neoplasms including 2 leiomyoma, 1 lipoma and 2 adenocarcinoma were diagnosed. The pathological changes in both cervix and vagina were the lowest affections and they were mainly inflammatory in reaction.