Background: Different Matrix metalloproteinases (MMPs) family members may be
implicated in acne vulgaris development. However, there are no published data about
the role of MMP-1
and TIMP-1
gene polymorphisms in acne vulgaris development.
Aims: To evaluate the association between MMP-1
(519 A/G) and TIMP-1
(372 T/C)
gene polymorphisms and the risk of developing acne vulgaris among a sample of
Egyptian acne patients.
Patients/Methods: This case-control
study included 100 acne vulgaris patients and
120 apparently healthy control subjects. Acne severity was assessed according to
Global Acne Grading System (GAGS). MMP-1
(519 A/G) and TIMP-1
(372 T/C) gene
polymorphisms were investigated using RFLP-PCR
technique.
Results: The MMP-1
(519 A/G) AG and GG genotypes and G allele increase the risk
of acne vulgaris~2–3
folds. In female patients, TIMP-1
(372 C/T) TT genotype and T
allele showed significantly higher frequency in cases compared with the control group
(p = 0.004, 0.001 respectively) with a higher risk to develop acne. On the other hand,
in male patients, there was insignificant difference between the frequency of alleles
in patients and control subjects. TIMP-1
(372C/T) TT genotype has been shown to be
significantly detected in the studied female patients associated with the positive family
history of the disease, and it increases the risk of back affection, severe acne grade
development, and the liability to postacne scar formation.
Conclusion: MMP-1
(519 A/G) and TIMP-1
(372 T/C) gene polymorphisms may be
related to acne vulgaris development.