Stem cell therapy is an important catigory of regenerative medicine has the potential to provide a valuable adjunct andalternative to liver transplantation with treatment of liver fibrosis and cirrhosis. In this approch, 70 male albino rats wererandomly divided into 4 groups: Group 1: Control group (20 rats), Group 2: TAA-treated group (20 rats), Group 3:Mesenchymal stem cells treated group (15 rats) and Group 4: TAA- Mesenchymal stem cell –treated group (15 rats). Ourresults showed that TAA is significantly increase the activities of ALT, AST, and ALP and reduced the levels of totalprotein, albumin and globulins in the serum. Moreover, TAA successfully induced liver cirrhosis characterized by coarsenodular liver surface with severe fibrous connective tissue proliferation led to pseudolobulation of hepatic parenchyma.Meanwhile, after treatment with Mesenchymal stem cells (MSCs) the liver of the rats was grossly nearly normal andmicroscopically thin strands of fibrous connective tissue in between the hepatic lobules with mild degenerative andnecrotic changes and significant improvement in the liver blood parameters. These findings concluded that MSCs haveameliorative effect on chemically induced liver cirrhosis through their regenerative capacity and antifibrotic effect.