Hyperketonemia and hypoglycemia are more common obvious biochemical features of pregnancy toxemia as well as liver and kidney may be involved in the pathogenesis of toxemia. Fifteen pregnant goats with twins (3-4 years, 20-27 kg body weight and 120-130 days of gestation) were classified into two groups, control one consists of six goats and experimental group consists of nine goats for induction of pregnancy toxemia by the stress of fasting with access of water until the symptoms of pregnancy toxemia were appeared within 72 hours. Serum samples were obtained and analyzed for β-hydroxybutyrate, glucose, total protein, albumin, globulin, urea, creatinine, AST, ALT, total lipids, cholesterol, calcium, magnesium, phosphorus, sodium and potassium using kits, while insulin, cortisol, T3, T4, growth hormone were measured by radioimmunoassay. Hematological profile was investigated on whole blood samples. β-hydroxybutyrate, AST, ALT, urea, creatinine, cortisol and insulin hormones were significantly higher in toxemic goats than those of control ones while glucose, sodium, potassium, calcium, magnesium, T4, total protein, globulin, albumin, cholesterol and total lipids values were significantly lower in toxemic goats than those of control ones while, there were no significant changes in phosphorous, T3 and growth hormone. A significant increase in leucocytes, hemoglobin, packed cell volume and neutrophils and a significant decrease in lymphocytes were observed in pregnancy toxemic goats than those of control ones. Clinical chemistry of pregnancy toxemia can affect hormonal, electrolytes and mineral balance as well as immune and hematological picture in goats.