An analysis is carried out to study the problem of heat and mass transfer flow over a moving permeable flat stretching sheet in the presence of convective boundary condition, slip, radiation, heat generation/absorption, and first-order chemical reaction. The viscosity of fluid is assumed to vary linearly with temperature. Also the diffusivity is assumed to vary linearly with concentration. The governing partial differential equations have been reduced to the coupled nonlinear ordinary differential equations by using Lie group point of transformations. The system of transformed nonlinear ordinary differential equations is solved numerically using shooting techniques with fourth-order Runge-Kutta integration scheme. Comparison between the existing literature and the present study was carried out and found to be in excellent agreement. The effects of the various interesting parameters on the flow, heat, and mass transfer are analyzed and discussed through graphs in detail. The values of the local Nusselt number, the local skin friction, and the local Sherwood number for different physical parameters are also tabulated.