Background:Tuberculosis (TB) is a major cause of illness and death worldwide, especially
in Asia and Africa. In the early 1990s tuberculosis control in Egypt faced many problems. Major progress in global tuberculosis control followed the widespread implementation of the DOTS strategy.
Aim:The objective of this work was to study the tuberculosis situation in Port Said governorate
from (1995–2011) before and after Direct Observed Therapy Short Course Strategy (DOTS).
Methods:This was a retrospective clinical cohort study carried out at the Port Said governorate.
The registered data about all TB cases over a period of 16 years (1995–2011) before and after the
application of DOTS were collected from the chest hospital and TB registration units.
Results:Percentages of cure and complete treatment significantly increased after DOTS (48.7%
and 29.3% respectively) than before (19.5% and 13.7% respectively) (P< 0.001). On the other hand,
failure, death, default and transfer out decreased after DOTS (5.9%, 3.2%, 7.5% and 5.4% respectively) than before it (6.5%, 6.1%, 34.7% and 19.5% respectively), the results were significant
(P< 0.05) for all of them except treatment failure. The mean values of incidence rates (new and
relapse cases, all cases and new smear positive pulmonary TB cases) of TB significantly (P< 0.05)
decreased after the application of DOTS. Also, the cure rate and treatment success rate significantly
increased (P= 0.001), while retreatment TB cases rate, default rate, transfer out rate and retreatment
failure rate significantly decreased (P< 0.05). Finally new pulmonary TB cases with no smear result
significantly (P< 0.05) increased after DOTS.
Conclusion:The introduction of DOTS in the Port Said governorate has led to a significant
increase in the treatment success (82.7%) (Near the WHO target ‘‘85%’’), and a decrease in the
default and failure rates.