Background Silent mating type information regulation 2
homolog 1 (SIRT1) and claudin 4 have been implicated in
tumorigenesis in many cancers, but their significance in
gastric carcinoma (GC) remains unclear. The aim of this
study was to assess their possible significance in GC.
Materials and methods Immunohistochemistry was
performed to examine the expression of SIRT1 and claudin
4 in 68 cases of GC and three adjacent precursor lesions
(chronic gastritis, intestinal metaplasia, and dysplasia).
Statistical analysis methods were used to evaluate the
relationship between SIRT1 and claudin 4 and various
clinicopathological parameters.
Results SIRT1 and claudin 4 were found highly expressed
in GC. The two markers significantly correlated with depth
of tumor invasion, distant metastasis, and TNM stage.
SIRT1 was positively correlated with advanced tumor
grade, whereas claudin 4 was inversely correlated with it.
No significant correlation between SIRT1 and claudin
4 was detected.
Conclusion The results suggested that both SIRT1 and
claudin 4 might be involved in gastric carcinogenesis.
The more advanced the TNM GC stage, the higher the
expression of SIRT1 and claudin 4. This suggests
their possible role in GC progression