أعضاء هيئة التدريس - جامعة بنها
Microvessel quantitation in primary urinary bladder carcinoma. Benha Med. J. 14(2): 914-501.
• 1997
معلومات البحث
المؤلفون
H.A. Agina; Ragaey R. Fahmy; and M. H. El-Mahdy
الكلمات المفتاحية
Not Available
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Determination of the prognostic value of cyclin D1, C-erb B-2, Ki-67 and the nucleolar organizer regions (AgNORs) in breast cancer
Ragaey R. Fahmy M.D.
Department of Pathology, Benha Faculty of Medicine, Benha University
Abstract:
Four different types of measurements of prognostic factors (cyclin D1, C-erb B-2, Ki-67 and AgNORs) were applied to a series of 70 breast lesions representing, 35 cases of invasive ductal carcinoma, 10 cases of invasive lobular carcinoma, 5 cases of tubular carcinoma, 10 cases of ductal carcinoma in situ, 10 cases of atypical ductal hyperplasia (ADH), in addition to 7 cases of normal breast tissue as a control, in combination with clinicopathological parameters to evaluate their prognostic significance in breast cancer. Expression of cyclin D1 is negative in atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). However, in 29/50 (58%) of invasive cancer breast, positive expression of cyclin D1 was observed. There is a significant association was observed between cyclin D1 expression and distant metastasis, recurrence, and five-year survival rate of the patients with breast cancer. There is also a significant correlation between C-erb B-2 expression and distant metastases, recurrence and 5-year survival rate. The Ki-67 label index and AgNORs count was found to correlate significantly and increased gradually with progression of breast lesions. The AgNORs size, shape and distribution was found to show a characteristic difference between benign, atypical and malignant groups. Malignant cells were characterized by an irregularly scattered distribution of AgNORs and by a pleomorphic size and shape of the dots in comparison to the round, uniform and regular size and shape of the AgNORs dots in benign lesions. Positive expression of cyclin D1, C-erb B-2, Ki-67 and high AgNORs score could be serve as a poor prognostic markers for patients with breast carcinoma independent of nodal metastases and clinical parameters, also expression of cyclin D1 could help in diagnosis of early invasion of breast carcinoma.
Research in Benha M.J. 25 (1)(2008): 375–394
Ragaey R. Fahmy M.D.
Department of Pathology, Benha Faculty of Medicine, Benha University
Abstract:
Four different types of measurements of prognostic factors (cyclin D1, C-erb B-2, Ki-67 and AgNORs) were applied to a series of 70 breast lesions representing, 35 cases of invasive ductal carcinoma, 10 cases of invasive lobular carcinoma, 5 cases of tubular carcinoma, 10 cases of ductal carcinoma in situ, 10 cases of atypical ductal hyperplasia (ADH), in addition to 7 cases of normal breast tissue as a control, in combination with clinicopathological parameters to evaluate their prognostic significance in breast cancer. Expression of cyclin D1 is negative in atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). However, in 29/50 (58%) of invasive cancer breast, positive expression of cyclin D1 was observed. There is a significant association was observed between cyclin D1 expression and distant metastasis, recurrence, and five-year survival rate of the patients with breast cancer. There is also a significant correlation between C-erb B-2 expression and distant metastases, recurrence and 5-year survival rate. The Ki-67 label index and AgNORs count was found to correlate significantly and increased gradually with progression of breast lesions. The AgNORs size, shape and distribution was found to show a characteristic difference between benign, atypical and malignant groups. Malignant cells were characterized by an irregularly scattered distribution of AgNORs and by a pleomorphic size and shape of the dots in comparison to the round, uniform and regular size and shape of the AgNORs dots in benign lesions. Positive expression of cyclin D1, C-erb B-2, Ki-67 and high AgNORs score could be serve as a poor prognostic markers for patients with breast carcinoma independent of nodal metastases and clinical parameters, also expression of cyclin D1 could help in diagnosis of early invasion of breast carcinoma.
Research in Benha M.J. 25 (1)(2008): 375–394