Nitric oxide is a common mediator for the action of adiponectin and
myeloperoxidase (MPO). Its importance is as a predictor of acute myocardial
infarction (AMI) severity.
Aim
The aim of the present study was to find a relationship between plasma adiponectin
level, MPO activity, lipid profile, serum nitrite/nitrate, and severity of AMI disease.
Patients and methods
To achieve this aim, 30 patients with AMI with age ranged from 35 to older than 70
years and 10 clinically healthy participants as control were subjected to this study.
Results
The result of this study showed a significant association between the occurrence of
AMI and low adiponectin level, high MPO activity, low nitrite level, high total
cholesterol level, high triacylglycerol level, high low-density lipoproteincholesterol
level, low high-density lipoprotein-cholesterol level, and high lowdensity
lipoprotein-cholesterol/high-density lipoprotein-cholesterol ratio. These
parameters may all be regarded as predictors or risk factors for AMI.
Conclusion
The findings of the present study suggest that hyperlipidemia, vascular
inflammation, and oxidative stress are primary interacting mediators in the
pathogenesis of AMI.