The present study aimed to evaluate the protective effect and treatment of olive
leaves administration on cardiac necrosis markers, some electrolytes, and cardiac
tissue antioxidants in myocardial necrosis induced experimentally in rats by
subcutaneous injection of isoproterenol (ISO).
Results
ISO-induced myocardial infarction in male rats resulted in a significant increase
in creatine kinase, creatine kinase MB, lactate dehydrogenase, aspartate
aminotransferase, glucose, potassium, and phosphorus in serum, in addition to
a significant increase in glucose-6-phosphate dehydrogenase in red blood cells. In
addition, it resulted in a significant decrease in serum calcium and sodium in serum.
Furthermore, this study demonstrated that there was a significant decrease in heart
tissue superoxide dismutase and a significant decrease in catalase activity, as well
as a significant increase in heart l-malondialdehyde levels, in ISO-injected rats.
Conclusion
This study shows that that olive leaves administration is effective against
myocardial infarction and oxidative damage in heart tissue induced by ISO in rats.