Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have severe
health problems require systemic steroids and multiple sinus surgery, Dupilumab is a new
biological treatment of type 2 inflammation by its effect on interleukin 4 and interleukin 13
which used in atopic dermatitis and bronchial asthma. Aim of the work is to investigate the
effect of High irrigation nasal steroids versus intranasal steroids in chronic sinusitis with
polypi under treatment of dupilumab. Patients and Methods: This study included 70
patients under treatment of dupilumab 300 mg in the form of injection every 2
weeks for 24 weeks, the patients divided into GI n=35 who receive high irrigation
nasal steroid and GII n=35 who receives nasal steroids for 24 weeks, this study
assess the management Plan for chronic sinusitis with nasal polypi as regards nasal
congestion, smell score, nasal endoscopy score, CT score (Lund Mackay).
Results: This study found that both techniques improve nasal congestion score which is
significant p