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Serum Level of Growth Arrest–Specific 6 (Gas6)Protein and Genetic Variations in the Gas6 Gene inPatients with Type 2 Diabetes Mellitus

• 2015
العودة
معلومات البحث
المؤلفون Nehad A Fouad. Sheref M Eltaher, Omminea A Abdullah, Ramy A Metwally
الكلمات المفتاحية Not Available
المجلة العلمية Not Available
الناشر Not Available
المجلد Not Available
العدد Not Available
الصفحات Not Available
publication.type International
رابط البحث Not Available
المواد المرفقة Not Available
الملخص
Growth arrest-specific protein 6 (Gas6) belongs to a family of vitamin K-dependent ‎coagulation proteins.
Plasma levels of Gas6 are associated to altered glucose tolerance. This study aimed at determining whether
c.843+7G>A Gas6 polymorphism is associated with the development of ‎type 2 diabetes mellitus.‎ The study
included ‎ ‏05‏ ‎ patients with type 2 diabetes and 40 matched controls. The Gas6 protein was measured in serum
using ELISA and Gas6 gene polymorphism by polymerase chain reaction-‎Restriction Fragment Length
‎Polymorphism.‎ The GG genotype was the most prevalent in the diabetic ‎patient. The frequency of A allele in
the diabetic group was lower than the control ‎group (P‎