أعضاء هيئة التدريس - جامعة بنها
Significant hepa c expressi on of IL-2 and I L-8 i n bil iary atr esi a compa r ed wit h other neonatal cholesta c di sor der s
• 2016
معلومات البحث
المؤلفون
Reda S Arafa, MD; Omima M Abdel Haie, MD; Dina S El-Azab, MD; Amira M Abdel-Rahman, MSc; Mostafa Mohamed Sira, M.D
الكلمات المفتاحية
biliary atresia; interleukin 2, interleukin 8, e opat hogenesi s; i mmu nostai ni ng,
neonatal cholestasis
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Objectives: Although the exact etiology of biliary atresia (BA) is still elusive, inflammation
plays a key role. Release of proinflammatory cytokines from activated immune cells
perpetuates the injury and causes biliary destruction. We aimed to study interleukin (IL)-2 and
IL-8 expression in liver tissue of BA patients compared with other neonatal cholestatic
disorders. Methods: The study included 59 infants with neonatal cholestasis in two groups;
BA group (n=31) and non-BA group (n=28) with cholestatic disorders other than BA as
controls. Demographic, clinical, laboratory, and histopathological parameters were collected.
IL-2 and IL-8 immunostaining was performed. Immunostaining in portal cellular infiltrate
was scored as positive or negative and expressed as the mean cell count in three portal tracts.
Results: The mean value of IL-2 and IL-8 positive inflammatory cells was significantly
higher in BA than in non-BA group (P-values of 0.004 and 0.002 respectively). IL-2
correlated significantly with IL-8 immunostaining in both BA and non-BA group (P
plays a key role. Release of proinflammatory cytokines from activated immune cells
perpetuates the injury and causes biliary destruction. We aimed to study interleukin (IL)-2 and
IL-8 expression in liver tissue of BA patients compared with other neonatal cholestatic
disorders. Methods: The study included 59 infants with neonatal cholestasis in two groups;
BA group (n=31) and non-BA group (n=28) with cholestatic disorders other than BA as
controls. Demographic, clinical, laboratory, and histopathological parameters were collected.
IL-2 and IL-8 immunostaining was performed. Immunostaining in portal cellular infiltrate
was scored as positive or negative and expressed as the mean cell count in three portal tracts.
Results: The mean value of IL-2 and IL-8 positive inflammatory cells was significantly
higher in BA than in non-BA group (P-values of 0.004 and 0.002 respectively). IL-2
correlated significantly with IL-8 immunostaining in both BA and non-BA group (P