Oxacar5azepine (0XC) is a new antiepileptic drug structurally related to earba.mazepine. It has shown a powerf1.4 protective effect against generalized tonic-clonic seizures with better tolerability and fewer side effects, This study was designed to detect changes in the level of neurotransmitters in different brain regions of rats with chemically-induced epilepsy pretreated by oxcarbazepine for 4 weeks compared to control epileptic. and normal rats. Biochemical and the histopathological changes which could occur after prolonged use of oxcarbazepine in liver and kidney of these rats were also explored. Oxcarbazepine treatment abolished all phases of major generalized tonic-clonic chemically-induced seizures. accarbazepine signifi-cantly reduced the concentration of dopamine and noradrenaline and increased GABA concentration in all tested brain regions of treated -rats. Oxcarbazepine treatment insignificantly alter biochemical parameters related to liver functions in the form of slight elevation of alkaline phosphatase and transarnina sit enzymes activities., However, Oxcarbazepine induced a significant hyponatrernia and insignificant changes in serum creatinine and blood urea. Similarly, histopathologieal studies of oxcarbazepine treated rats 'revealed some minor changes such as dilatation and congestion of the central vein and blood sinusoids .of the liver and glomcrular hypercellularity with hyaline deposites and dilated cortical tubules in the kidney. In. conclusion, oxcarbazecline could. be used effectNiely and safely as a monotherapy in epilepsy However, liver and kidney functions and serum electrolytes sould be monitored on prolonged use.